Noscapine Base API: Micronized & injectable Non-Narcotic Alkaloid Grades

Noscapine Base is a cough suppressant (antitussive) primarily used to provide short-term relief from dry, non-productive coughs. It works by acting directly on the cough center in the brain to reduce the urge to cough. a centrally-acting cough suppressant and one of several alkaloids present in papaveretum (opium concentrate) was introduced into medicine many years ago. Subsequently, it was shown to increase the number of chromosomes in mammalian cell lines maintained in vitro. Although the clinical significance of this finding is uncertain, restrictive action was taken in a few countries since the possibility of a genotoxic effect cannot be excluded. On 4 December 1992 the European Committee on Proprietary Medicinal Products concluded that the available evidence does not indicate that use of noscapine holds any significant hazard. The Swedish Medical Products Agency also concluded that there is no justification to restrict the use of noscapine in women of childbearing age.