Buprenorphine Base API: Injectable & Micronized High-Purity Grades

Buprenorphine Base is a semi-synthetic highly lipophilic opioid derivative. It acts as a partial agonist at the mu-opioid receptor and an antagonist at the kappa-opioid receptor. Due to its unique pharmacological profile, including a "ceiling effect" on respiratory depression and a long duration of action, it is the primary API used in Opioid Use Disorder (OUD) maintenance and the management of moderate-to-severe chronic pain.

At Micro Orgo Chem (MOC), we manufacture Buprenorphine Base in our GMP certified facility under stringent narcotic controls. We specialize in Micronized Grades with precision-controlled Particle Size Distribution (PSD) to ensure optimal bioavailability in sublingual and transdermal delivery systems. We also offer a validated Injectable Grade processed under strict aseptic conditions for the development of long-acting depot formulations.

Our API is compliant with USP, EP (Ph. Eur.), and IP pharmacopeias, offering high impurity control and absolute polymorphic stability.